strange motherboard noise

I have an HP XW6400 workstation that was recently gifted to me.

I am hearing a strange noise. Only happens inside of windows. Sort of sounds like the really old hard drives from the late 80s early 90s that were loud as hell. It seems to happen when I am loading something.

Machine is using a brand new WD Blue 1TB. The sound is coming from the motherboard (definitely) and NOT the drive.

Thoughts?